Related Subunits of NF-KB Map to Two Distinct Loci Associated with Translocations in Leukemia, NFKBI and NFKBZ
نویسنده
چکیده
The chromosomal locations of the human genes NFKBl and NFKBP, which encode two alternative DNA binding subunits of the NF-KB complex, ~105 andp49/plOO, respectively, have been determined. ~105 was assigned to 4q21.1-q24 and p49/ ~100 to chromosome 10 by Southern blot analysis of panels of human/Chinese hamster cell hybrids. The locations were confirmed by fluorescence in situ hybridization and mapped with greater resolution to 4q23 and lOq24, respectively. These results demonstrate that these members of the NF-KB family are unlinked. Interestingly, p49/plOO as well as ~105 maps to regions associated with certain types of acute lymphoblastic leukemia.
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